Systematically Improving Espresso: Insights from Mathematical Modeling and Experiment

Improving Control of Tuberculosis in Low-Burden Countries: Insights from Mathematical Modeling

Tuberculosis control and elimination remains a challenge for public health even in low-burden countries. New technology and novel approaches to case-finding, diagnosis, and treatment are causes for optimism but they need to be used cost-effectively. This in turn requires improved understanding of the epidemiology of TB and analysis of the effectiveness and cost-effectiveness of different interv...

Cardiac repolarization: insights from mathematical modeling and electrocardiographic imaging (ECGI).

Cardiac repolarization is a complex rate dependent process. At the cellular level, it depends on a delicate dynamic balance of ion channel currents. At the heart level, it is spatially heterogeneous, leading to spatial gradients of potential and excitability. This article provides insights into the molecular mechanisms of the delayed rectifiers I(Kr) (rapid) and I(Ks) (slow) that underlie effec...

Electrotherapy on Cancer: Experiment and Mathematical Modeling

The force-frequency relationship: insights from mathematical modeling.

The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple formulation of Koch-Wesser and Blinks in 1963 to the most sophisticated ones of today. This property of cardiac muscle is amplified by β-adrenergic stimulation, and, in a coordinated ...

Historical Perspectives The force-frequency relationship: insights from mathematical modeling

Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. The forcefrequency relationship: insights from mathematical modeling. Adv Physiol Educ 37: 28–34, 2013; doi:10.1152/advan.00072.2011.—The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple form...